Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents
Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juve...
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Format: | Electronic Article |
Language: | English |
Published: |
2016
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In: |
European archives of psychiatry and clinical neuroscience
Year: 2016, Volume: 266, Issue: 8, Pages: 771-773 |
Online Access: |
Volltext (Verlag) |
Journals Online & Print: | |
Check availability: | HBZ Gateway |
Keywords: |
Summary: | Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia ( n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania. |
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ISSN: | 1433-8491 |
DOI: | 10.1007/s00406-015-0664-3 |