Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents

Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juve...

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Bibliographic Details
Main Author: Isaksson, Johan (Author)
Format: Electronic Article
Language:English
Published: 2016
In: European archives of psychiatry and clinical neuroscience
Year: 2016, Volume: 266, Issue: 8, Pages: 771-773
Online Access: Volltext (Verlag)
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Keywords:
Psychopathie
Psychopathy
Genetic aspects
Genetik
Conduct disorder
Description
Summary:Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia ( n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.
ISSN:1433-8491
DOI:10.1007/s00406-015-0664-3