RT Article
T1 Assessing the Effect of Firearms Regulations Using Partial Identification Methods: A Case Study of the Impact of Stand Your Ground Laws on Violent Crime
JF PLOS ONE
A1 Edlund, Karolina
A2 Yamamoto, Tadashi
A2 Uhlen, Mathias
A2 Sivertsson, Asa
A2 Pontén, Fredrik
A2 Odeberg, Jacob
A2 Kampf, Caroline
A2 Hallstrom, Bjorn M.
A2 Habuka, Masato
A2 Fagerberg, Linn
LA English
YR 2014
UL https://krimdok.uni-tuebingen.de/Record/1866308122
AB To understand renal functions and disease, it is important to define the molecular constituents of the various compartments of the kidney. Here, we used comparative transcriptomic analysis of all major organs and tissues in the human body, in combination with kidney tissue micro array based immunohistochemistry, to generate a comprehensive description of the kidney-specific transcriptome and proteome. A special emphasis was placed on the identification of genes and proteins that were elevated in specific kidney subcompartments. Our analysis identified close to 400 genes that had elevated expression in the kidney, as compared to the other analysed tissues, and these were further subdivided, depending on expression levels, into tissue enriched, group enriched or tissue enhanced. Immunohistochemistry allowed us to identify proteins with distinct localisation to the glomeruli (n=11), proximal tubules (n=120), distal tubules (n=9) or collecting ducts (n=8). Among the identified kidney elevated transcripts, we found several proteins not previously characterised or identified as elevated in kidney. This description of the kidney specific transcriptome and proteome provides a resource for basic and clinical research to facilitate studies to understand kidney biology and disease
DO 10.1371/journal.pone.0116125